Proinflammatory cytokine polarization in type 2 diabetes
نویسندگان
چکیده
منابع مشابه
The implication of proinflammatory cytokines in type 2 diabetes.
The incidence of type 2 diabetes (T2D) is rapidly expanding. Some of the more obvious pathologies associated with it include: defective glucose metabolism, obesity, cardiovascular disease and an inability to mount an effective immune response to infection by certain pathogenic organisms, leading to sepsis and death. A common tie linking these seemingly disparate complications is chronic inflamm...
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Introduction: Type 2 diabetes (T2D) is chronic health caused by the interaction between genetic and environmental factors that results in high blood glucose. The evidence-based guidelines for diabetes management are mainly based on lifestyle changes, control of risk factors, and the management of blood glucose levels. Although numerous antidiabetic agents have been developed over time, T2D trea...
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The proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)are thought to impair insulin signaling (1,2), and abnormally high levels of them are associated with insulin resistance (3,4) and type 2 diabetes (3,5). In patients with type 2 diabetes, a meal rich in fat, mainly in the form of sausages and butter, increases postprandial plasma concentrations of IL-6 and TNF, wher...
متن کاملCytokine profile and lymphocyte subsets in type 2 diabetes.
Type 2 diabetes mellitus (T2D) is a metabolic disease with inflammation as an important pathogenic background. However, the pattern of immune cell subsets and the cytokine profile associated with development of T2D are unclear. The objective of this study was to evaluate different components of the immune system in T2D patients' peripheral blood by quantifying the frequency of lymphocyte subset...
متن کاملGenetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes
BACKGROUND The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of variants previously reported to be associated with atopic diseases and epitheli...
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ژورنال
عنوان ژورنال: Central European Journal of Immunology
سال: 2020
ISSN: 1426-3912
DOI: 10.5114/ceji.2020.97904